Product Description
Ivabradine is a Hyperpolarization-activated Cyclic Nucleotide-gated Channel Blocker. The mechanism of action of ivabradine is as a Hyperpolarization-activated Cyclic Nucleotide-gated Channel Antagonist.
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Mechanism of Action and UsageIvabradine acts by selectively inhibiting the If current in the sinoatrial node, thereby reducing heart rate. Its targeted usage makes it suitable for individuals with chronic stable angina who cannot take beta-blockers, as well as for patients with certain types of heart failure. This characteristic benefits those seeking effective heart rate management under physician supervision.
Quality and Physical PropertiesWith a high purity of 99%, Ivabradine is available as a hygroscopic powder, ensuring ease of formulation and consistent quality. It boasts impressive solubility in solvents like dimethylsulphoxide, methanol, water, and methylene chloride, supporting diverse pharmaceutical manufacturing processes. The melting point of 193-196C and boiling point of 626.9C attest to its chemical stability.
FAQ's of Ivabradine:
Q: How does Ivabradine lower heart rate in patients with angina and heart failure?
A: Ivabradine reduces heart rate by selectively inhibiting the If current in the heart's sinoatrial node. This mechanism slows down the heart, making it effective for treating chronic stable angina and heart failure when beta-blockers are not suitable.
Q: What are the physical and chemical characteristics of Ivabradine powder?
A: Ivabradine is a hygroscopic powder with a purity of 99%. It is freely soluble in dimethylsulphoxide and methanol, soluble in water and methylene chloride, and features a melting point of 193-196C. Its molecular formula is C27H36N2O5, and it has a molecular weight of 468.594 g/mol.
Q: When should Ivabradine be considered for use in heart conditions?
A: Ivabradine is prescribed when patients suffer from chronic stable angina or heart failure and are unable to take beta-adrenergic blockers. Its usage should always be under the direction of a qualified healthcare professional.
Q: Where can Ivabradine be sourced for pharmaceutical applications?
A: Ivabradine is available through dealers, distributors, exporters, manufacturers, suppliers, traders, and wholesalers across India. It accommodates bulk sourcing for further formulation or distribution.
Q: What is the process for using Ivabradine in medication manufacturing?
A: Ivabradine's powder form and high solubility make it suitable for compounding or tablet preparation in pharmaceutical manufacturing. The production process must ensure controlled handling due to its hygroscopic nature.
Q: What are the primary benefits of Ivabradine for cardiovascular patients?
A: The main benefit of Ivabradine is its ability to lower heart rate, thereby reducing cardiac workload. This is especially valuable for patients with angina or heart failure who cannot use standard beta-blocker therapies.